Rensselaer Polytechnic Institute: Structural Bioinformatics Laboratory
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Gaetano T. Montelione Laboratory
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The Rensselaer Polytechnic Institute: Structural Bioinformatics Laboratory carries out structure and function studies of genomically-defined protein targets. The lab uses both NMR and X-ray crystallography, along with computational methods, to address questions emerging from genomic and functional genomic analyses. The lab also develops software to automate structure determination by NMR methods.

  • Nature Methods: Solving Large Protein Structures By NMR. Two papers address this challenge by presenting hybrid methods that couple sparse NMR information with alternative structural information in order to solve protein structures. Read the full article here: Nature Methods
  • Congratulations to Christopher Kim on admission to University of Iowa's Summer Undergraduate MSTP Research (SUMR) Program. Chris is working in the Montelione lab in collaboration with Shridar Ganesan, CINJ, researching the suppression of oncogenic TRIM fusion proteins by arsenic.
  • Congratuations to lab alumnus Adam Schwing (MBB 2016) on his acceptance into New York University's M.D/Ph.D. program this July. While in our lab, Adam wrote his honors thesis on "Solution NMR Studies of the Complex Formed Between the Human Retinoblastoma-associated Protein and the Human Adenovirus E1A Protein."
95 Undergraduates trained in Montelione Lab
 IN THE NEWS:
  • Cu-binding proteins as targets for Staphylococcus aureus (MRSA) antibiotics: Sciencedaily.com Technology Networks
  • Towards more powerful asprin-like drugs
  • Why influenza B virus exclusively infects humans
  • Restrained Rosetta for NMR structure refinement
  • Data mining shows that NMR and X-ray crystallography are complementary
  • Nexomics Biosciences: A Rutgers CRO in structural biology
 SOFTWARE:
  • ASDP Software for automated NOESY analysis
  • The Protein Structure Validation Suite (PSVS)
  • DISMETA: Disorder prediction metaserver
  • PDBStat Software for structural bioinformatics

Center for Biotechnology and Interdisciplinary Studies, 1623 15th Street, Troy, NY, 12180
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